This paper develops ARCADE, a high-throughput assay to profile antiviral antibody responses, showing mRNA vaccines elicit broader and stronger responses than adenovirus vector vaccines.

bioRxiv · Jan 6, 2026 · PreprintImmunology

Enabling large-scale genome editing by reducing DNA nicking

Cory J. Smith, Oscar Castanon, Khaled Said, Verena Volf, Parastoo Khoshakhlagh, Amanda Hornick, Raphaël Ferreira, Chunting Wu, Marc Güell, Shilpa Garg, Alex H. M. Ng, Hannu Myllykallio, George McDonald Church

This paper develops dead-Cas9 base editors that enable large-scale genome editing in human cells by reducing DNA nicking, allowing editing of over 10,000 loci.

Nucleic Acids Research · Apr 1, 2020Peer-reviewedSynthetic Biology

Rapid and scalable in vitro production of single-stranded DNA

Dionis Minev, Richard Guerra, Jocelyn Y. Kishi, Cory J. Smith, Elisha Krieg, Khaled Said, Amanda Hornick, Hiroshi M. Sasaki, Gabriel T. Filsinger, Brian J. Beliveau, Peng Yin, George McDonald Church, William M. Shih

This paper describes a method for producing high-purity single-stranded DNA for various applications.

bioRxiv · Feb 22, 2019 · PreprintMolecular Biology