Epigenomic subtypes of late-onset Alzheimer's disease reveal distinct microglial signatures
Valentin Laroche, Rachel Cavill, Morteza P Kouhsar, Joshua Müller, Rick A. Reijnders, Joshua Harvey, Adam R. Smith, Jennifer L. Imm, Jarno Koetsier, Luke Stephen Weymouth, Lachlan Ford MacBean, Giulia Pegoraro, Lars Eijssen, Byron Creese, Günter Kenis, , Ehsan Pishva
This study identifies two epigenomic subtypes of late-onset Alzheimer's disease with distinct microglial and neuronal methylation signatures, linking them to different inflammatory and functional pathways.
Acta Neuropathologica · Feb 24, 2026Peer-reviewedGenomics