Michelle J. Boyle

Repeated malaria exposure reprograms Vδ2+ γδT cell chromatin accessibility and immune function toward a reversible hyporesponsive state

Circulating T-follicular helper and type I regulatory T cells have overlapping phenotypes in P. falciparum malaria and are maintained by parasite exposure.

The paper characterizes malaria-specific Tfh and Tr1 cells in a longitudinal cohort, finding overlapping phenotypes and showing their decline after transmission interruption.

Cytotoxic Vδ2+T cell subsets expand in response to malaria in human tonsil and spleen organoids

This study shows that malaria exposure increases cytotoxic Vδ2+ T cell expansion in human tonsil and spleen organoids, with clonal expansion and activation, while not significantly affecting influenza vaccine responses.

Antibody responses against bacterial glycans affinity mature and diversify in germinal centers.

The paper shows that glycan-specific B cells undergo class-switching and diversification in germinal centers with age and infection, influencing vaccine design.

Comparison of CD4 T cell response in Plasmodium falciparum and vivax malaria

This study compares CD4 T cell responses to Plasmodium falciparum and P. vivax malaria, finding similar activation and proliferation but species-specific differences in peripheral Tfh cell subsets and IL-10 production.

Vγ1+ γδ T cell-derived IL-4 initiates CD8 T cell immunity

The paper shows Vγ1+ γδ T cells produce IL-4 to activate DC and CD8 T cells, enhancing immunity against Plasmodium.

Latent cytomegalovirus disrupts NK cell responses to P. falciparum and impairs parasite control

This study shows that latent cytomegalovirus infection reduces NK cell responses to Plasmodium falciparum and impairs parasite control by disrupting IL-12 production.

Age is an intrinsic driver of inflammatory responses to malaria

The paper investigates age-related differences in inflammatory responses to malaria, finding that adults exhibit heightened inflammatory cytokine production and distinct transcriptional responses compared to children.

Defining the roles of NKG7 expressed by CD4+ and CD8+ T cells during malaria

This study investigates the role of NKG7 in CD4+ and CD8+ T cells during malaria, showing protective and cell-intrinsic functions in different infection models and human infections.

Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

Heterogeneity of the human immune response to malaria infection and vaccination driven by latent cytomegalovirus infection

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.