Author

Zuleima Pava

Burnet InstituteORCID 0000-0002-4802-0647Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Christian R. EngwerdaiD· 4 shared Dean W. AndrewiD· 4 shared Jessica R. LoughlandiD· 4 shared Michelle J. BoyleiD· 4 shared Nicholas L. DooleyiD· 4 shared Bridget E. BarberiD· 3 shared Damian A. OyongiD· 3 shared James S. McCarthyiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersImmunology

Christian R. EngwerdaORCID

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5 papers

Recent·Most cited

Circulating T-follicular helper and type I regulatory T cells have overlapping phenotypes in P. falciparum malaria and are maintained by parasite exposure.

Mayimuna Nalubega, Damian A. Oyong, Dean W. Andrew, Megan S. F. Soon, Jessica R. Loughland, Zuleima Pava, Nicholas L. Dooley, Kenneth Musinguzi, Felistas Nankya, Isaac Ssewanyana, John Rek, Emmanuel Arinaitwe, Moses Robert Kamya, Margaret E. Feeney, Prasanna Jagannathan, , Michelle J. Boyle

The paper characterizes malaria-specific Tfh and Tr1 cells in a longitudinal cohort, finding overlapping phenotypes and showing their decline after transmission interruption.

bioRxiv · Jun 29, 2026 · PreprintImmunology

Latent cytomegalovirus disrupts NK cell responses to P. falciparum and impairs parasite control

Reena Mukhiya, Jessica R. Loughland, Nick Dooley, Zuleima Pava, Damian A. Oyong, Dean W. Andrew, Julianne Hamelink, Kiana Berry, James S. McCarthy, Bridget E. Barber, J. Alejandro Lopez, Christian R. Engwerda, Michelle J. Boyle

This study shows that latent cytomegalovirus infection reduces NK cell responses to Plasmodium falciparum and impairs parasite control by disrupting IL-12 production.

bioRxiv · Jan 28, 2026 · PreprintImmunology

Age is an intrinsic driver of inflammatory responses to malaria

Jessica R. Loughland, Nicholas L. Dooley, Zuleima Pava, Arya SheelaNair, Dean W. Andrew, Peta E. Tipping, Peter Bourke, Christian R. Engwerda, José Alejandro López, Kim A. Piera, Timothy William, Bridget E. Barber, Matthew J. Grigg, Nicholas M. Anstey, Gabriela Minigo, Michelle J. Boyle

The paper investigates age-related differences in inflammatory responses to malaria, finding that adults exhibit heightened inflammatory cytokine production and distinct transcriptional responses compared to children.

Nature Communications · Sep 30, 2025Peer-reviewedImmunology

Functionally Distinct pTfh1 Subsets with Roles in Malaria-Specific Immunity

Megan S. F. Soon, Damian A. Oyong, Nicholas L. Dooley, Reena Mukhiya, Zuleima Pava, Dean W. Andrew, Jessica R. Loughland, James S. McCarthy, Jo-Anne Chan, James G. Beeson, Christian R. Engwerda, Ashraful Haque, Michelle J. Boyle

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

bioRxiv · Feb 27, 2025 · PreprintImmunology

A molecular barcode and online tool to identify and map imported infection with Plasmodium vivax

Hidayat Trimarsanto, Roberto Amato, Richard D. Pearson, Edwin Sutanto, Rintis Noviyanti, Leily Trianty, Jutta Marfurt, Zuleima Pava, Diego F. Echeverry, Tatiana M. Lopera-Mesa, Lidia Madeline Montenegro, Alberto Tobón-Castaño, Matthew J. Grigg, Bridget E. Barber, Timothy William, , Sarah Auburn

The paper develops a molecular barcode and online tool to identify and map imported Plasmodium vivax infections using SNP analysis and machine learning.

Communications Biology · Dec 23, 2022Peer-reviewedMolecular Biology