James S. McCarthy

The paper characterizes and manufactures a Neisseria gonorrhoeae challenge agent for use in an oropharyngeal controlled human infection model, selecting a suitable isolate and validating a manufacturing workflow.

This study shows that latent cytomegalovirus infection reduces NK cell responses to Plasmodium falciparum and impairs parasite control by disrupting IL-12 production.

The paper maps the geographic distribution and host associations of MaRNAV-1, a virus linked to Plasmodium vivax, using metatranscriptomic data.

This study investigates the role of NKG7 in CD4+ and CD8+ T cells during malaria, showing protective and cell-intrinsic functions in different infection models and human infections.

The paper identifies two functionally distinct Tfh1 subsets in malaria infection, showing that only CCR7pos Tfh1 and Tfh2 cells are associated with antibody development.

This study shows that latent cytomegalovirus infection reduces antibody responses to malaria infection and vaccination by altering Tfh cell subsets and their activation.

This paper identifies M. ulcerans JKD8049 as a suitable human challenge strain for Buruli ulcer research due to its stability, antibiotic susceptibility, and ability to produce mycolactone.

This study models Plasmodium falciparum gametocyte dynamics in humans using a mathematical model validated by Bayesian inference, revealing key parameters affecting malaria transmission.

This paper completes the human malaria genome set by presenting reference genomes for Plasmodium malariae and P. ovale, revealing unique genomic features and cryptic species within P. ovale.