Civia Zi-Yu Chen

Imaging progenitor cell differentiation during central nervous system remyelination using an MRI gene reporter

This study develops an MRI-based method to track oligodendrocyte progenitor cell differentiation during remyelination in vivo using a gene reporter system.

Extrinsic cues unlock cross-germ layer differentiation potential of CNS stem cells during regeneration

The paper identifies integrin and BMP signaling pathways that drive OPC-to-SC differentiation in CNS regeneration using single-cell genomics.

A retroviral origin of vertebrate myelin

This study identifies a retroviral origin of vertebrate myelin by showing that RNLTR12-int retrotransposon regulates myelination through SOX10 interaction in multiple vertebrates.

SARM1 detection in oligodendrocytes but not Schwann cells though sarm1/Sarm1 deletion does not perturb CNS nor PNS myelination in zebrafish and mice.

The paper shows SARM1 is present in oligodendrocytes but not Schwann cells, and its deletion does not affect myelination in zebrafish or mice.

Proliferation is a requirement for differentiation of oligodendrocyte progenitor cells during CNS remyelination

This study shows that OPC proliferation is required for differentiation during CNS remyelination, revealing a link between proliferation and differentiation in OPCs.