Hanspeter Herzel

This study identifies cwo/Dec1 as a molecular mechanism linking the circadian clock to lunar phase in Platynereis dumerilii, showing its role in circalunar oscillation.

This study shows that extracellular circadian communication coordinates the circadian clock and cell cycle, and its disruption impairs tissue growth and links circadian disruption to oncogenic processes.

The paper investigates how circadian period compensates for fluctuations in repressor protein turnover rates in single cells using fluorescently labeled proteins and mathematical modeling.

The paper defines and analyzes two types of amplitude-period correlations in circadian rhythms and shows their impact on oscillator-environment interactions.

This study shows coupling enables robust circadian rhythms in redox oscillators despite noise and heterogeneity.

The paper uses gene expression signatures to predict circadian rhythms in EGFR, PI3K, and p53 pathways in mouse liver across multiple datasets.

This study examines circadian gene expression variability in human skin layers and identifies layer-specific biomarkers for internal clock phase.

The paper examines circRNA expression in circadian rhythms, finding that Cdr1as shows dynamic expression in the SCN and is linked to light-induced phase shifts.

This study investigates how temperature cycles affect circadian rhythms in Neurospora crassa, showing complex dynamics including entrainment, period-doubling, and aperiodic behavior through mathematical modeling.

The paper identifies posttranscriptional mechanisms, specifically involving CPSF6 and EIF2S1, that underlie circadian temperature compensation in U-2 OS cells.

The paper shows that Venn Diagram analysis overestimates differentially rhythmic transcripts and introduces an R-package to improve accuracy in circadian rhythm studies.

The paper models how multiple random phosphorylations in clock proteins generate delays and switches necessary for circadian oscillations.

The paper develops conceptual models of circadian entrainment using global optimization to explain phenotypic features like phase response curves and seasonal variability.

The paper shows that minimal clock models can reproduce essential circadian phenotypes like fast jetlag and seasonal shifts through amplitude effects and twist mechanisms.

The paper shows that weak coupling between feedback loops in circadian clocks leads to dissociated gene expression dynamics at the single-cell level.

The paper develops a mathematical model of the Neurospora crassa circadian clock to elucidate the mechanism of rhythms production and glucose compensation.

The paper develops a computational model to explain mitochondrial Prx/Srx redox oscillations in mammalian tissues, showing that delayed feedback and switches generate robust 24-hour rhythms.

The paper identifies tissue-specific circadian feedback loops by fitting mathematical models to gene expression data from different mammalian tissues.