Elizabeth I. Tilden

The paper identifies a molecular signal that encodes within-bout sleep history by showing PKA-SP decreases exponentially during sleep and integrates sleep duration and interruption.

This study demonstrates that fluorescence lifetime can accurately measure neuromodulator dynamics across animals and over time, overcoming limitations of intensity-based measurements.

The paper develops a Cre-dependent reporter mouse, FL-AK, for quantitative imaging of PKA activity dynamics in vivo and ex vivo.

This study shows that V1 neurons maintain stable firing rates during expected light-dark transitions but respond to unexpected changes, with correlations during natural vision being more informative than individual rates.