Yao Chen

The paper identifies a molecular signal that encodes within-bout sleep history by showing PKA-SP decreases exponentially during sleep and integrates sleep duration and interruption.

This paper develops highly sensitive chemigenetic FRET-based biosensors for kinase and signaling activity with improved dynamic range and spectral properties.

This paper introduces FLiSimBA, a simulation framework to analyze fluorescence lifetime data, revealing limitations and proposing advancements in FLIM for biological applications.

This study demonstrates that fluorescence lifetime can accurately measure neuromodulator dynamics across animals and over time, overcoming limitations of intensity-based measurements.

The paper develops a Cre-dependent reporter mouse, FL-AK, for quantitative imaging of PKA activity dynamics in vivo and ex vivo.

The paper introduces WHaloCaMP, a near-infrared calcium indicator, and demonstrates its use in imaging calcium responses in various organisms.

The paper shows dopamine modulates PKA in striatal neurons during reward learning, with D1R and D2R neurons responding oppositely to dopamine changes.