Oliver D. King

The paper uses spatial transcriptomics to identify immune and epithelial changes in oral premalignant lesions that precede cancer, revealing potential biomarkers and mechanisms for early interception.

This paper validates DNA methylation signatures for FSHD detection using D4Z4caster software and compares Sanger and NGS methods for improved diagnostic accuracy and accessibility.

This study shows that TDP-43 dysfunction impairs proteostasis and worsens neurological outcomes after brain injury in mice.

This study demonstrates that AAV9-CSA gene therapy extends lifespan and distributes human CSA in the brain and heart of Csa-/-;Xpa-/- mice, but also causes adverse effects.

This study shows CRISPR-Cas13b effectively reduces DUX4 in FSHD but is limited by immune responses that decrease Cas13b levels over time.

This study uses isogenic cerebral organoids to examine transcriptomic and cell-type differences between trisomic and disomic iPSC lines, finding that Trisomy 21 correlates with increased Aβ-40 levels but not other non-chr21 DEGs.