Hannah V. Bimschleger

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

This study identifies genomic loci associated with cue-reactivity in rats, linking them to incentive salience and drug abuse-related traits.

The paper genotypes Y and mitochondrial chromosomes in heterogeneous stock rats and finds no significant associations with complex traits, except for gene expression on these chromosomes.

This study performs a GWAS in HS rats to identify genetic loci associated with intraocular pressure, finding three genome-wide significant loci and five candidate genes, including novel ones.

The paper simulates GWAS in rats to show that larger sample sizes lead to an exponential increase in the number of significant loci detected.

This study identifies genetic loci associated with exploratory locomotion and anxiety-like traits in a selectively bred rat model using a genome-wide association approach.

This study identifies 30 genome-wide significant QTLs for open field behaviors in rats, with 13 candidate genes linked to psychiatric disorders in humans.

The paper adapts genotype-by-sequencing for HS rats to call and impute over 3.7 million SNPs with 99% concordance compared to a genotyping array.