Jonathon Cross

The paper develops a human cardiac microtissue model to study ischemia-reperfusion injury and shows that nanovesicles improve cardiomyocyte survival and function through proteomic changes.

This study shows that impairing polymerase gamma activity in cardiomyocytes leads to mtDNA instability, activates the integrated stress response, and causes severe cardiomyopathy with hepatopathy in mice.

This paper shows DRP1 inhibition reduces doxorubicin-induced cardiotoxicity while maintaining its anticancer effects in multiple cancer models.

This paper develops a device-encapsulated MSC system for sustained secretome delivery to treat ischaemic heart injury, showing improved cardiac function and reduced remodelling in rats.

The paper identifies hallmark protein and lipid features of circulating extracellular vesicles in humans using multi-omics analysis and provides an open-source tool for further exploration.