Markus J. T. Ojanen

This study identifies Scinderin as a regulator of Golgi actin remodeling that coordinates GLP-1 and insulin secretion, linking intracellular trafficking defects to glucose homeostasis and diabetes.

The paper identifies deep nuclear envelope invaginations (DINEs) in epithelial cells, showing they organize chromatin and gene activity in response to mechanical cues like crowding and tissue maturation.

This study shows that Atoh8 regulates M cell differentiation, with its absence increasing M cell numbers and transcytosis capacity, affecting mucosal immunity.