Fábio Tadeu Arrojo Martins

Scinderin-driven Golgi Actin Remodeling coordinates GLP-1 and insulin secretion to regulate glucose homeostasis

This study identifies Scinderin as a regulator of Golgi actin remodeling that coordinates GLP-1 and insulin secretion, linking intracellular trafficking defects to glucose homeostasis and diabetes.

Deep Invaginations of Nuclear Envelope Coordinate Spatial Organization of Chromatin in Epithelium

The paper identifies deep nuclear envelope invaginations (DINEs) in epithelial cells, showing they organize chromatin and gene activity in response to mechanical cues like crowding and tissue maturation.

Maf is a regulator of differentiation for gut immune epithelial cell Microfold cell (M cell)

This study identifies Maf as a critical regulator of M cell differentiation and maturation, showing that its absence leads to impaired development and reduced Gp2 expression.

Polycomb Repressive Complex 2-controlled Essrg regulates intestinal Microfold cell differentiation.

The paper identifies Essrg as a necessary factor for Sox8-mediated M cell differentiation, regulated by PRC2 during intestinal M cell development.

Spectrum of genes for inherited hearing loss in the Israeli Jewish population, including the novel human deafness gene ATOH1

The paper identifies genetic causes of inherited hearing loss in the Israeli Jewish population, finding a novel deafness gene ATOH1 and demonstrating the effectiveness of targeted genomic sequencing.