Author

Harald Wodrich

Centre National de la Recherche ScientifiqueORCID 0000-0002-4764-1708Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Nicolas LandreiniD· 2 shared Alexandra MülleriD· 1 shared Allan SauvatiD· 1 shared Anastasiia V. TymchenkoiD· 1 shared Ann E. TollefsoniD· 1 shared Anna Cline-SmithiD· 1 shared Benoı̂t Roger· 1 shared Charlotte Quentin-FroignantiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Nicolas LandreinORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A distinct signature of interferon-stimulated genes linked to cross-protection against secondary viral infections in primary bronchial epithelial cells

Anastasiia V. Tymchenko, Morgane Fierville, Pauline Estèves, Pierre Gourdan, Sophie Germain, Rihab Ben-Sghaier, Muriel Faure, Benoı̂t Roger, Fabienne Rayne, Nicolas Landrein, Virginie Magnone, Pascal Barbry, Patrick Berger, Fabien Beaufils, Laure‐Emmanuelle Zaragosi, , Thomas Trian

bioRxiv · Jul 1, 2026 · PreprintMicrobiology

Adenovirus maturation establishes the transcription competent packaging of its genome

Conradin Baumgartl, Simon Holzinger, Uwe Schwartz, Linda Elise Franken, Kay Grünewald, Harald Wodrich, Gernot Längst

This study identifies genomic regions that become decompacted during adenovirus maturation, revealing how DNA sequence features guide genome organization for transcription.

EMBO Reports · Oct 21, 2025Peer-reviewedMolecular Biology

Lysosomal membrane permeabilization enhances the anticancer effects of RNA Polymerase I transcription inhibitors

Lucille Ferret, Jonathan G. Pol, Allan Sauvat, Gautier Stoll, Karla Alvarez-Valadez, Alexandra Müller, Julie Le Naour, F. Peyre, Gerasimos Anagnostopoulos, Isabelle Martins, Maria Chiara Maiuri, Harald Wodrich, Lionel Guittat, Jean‐Louis Mergny, Guido Kroemer, Mojgan Djavaheri‐Mergny

This study shows that lysosomal membrane permeabilization enhances the effectiveness of RNA Polymerase I inhibitors against cancer cells.

Autophagy · Jun 18, 2025Peer-reviewedCancer Biology

LAVR-289, a New Orally Bioavailable Inhibitor of Adenovirus Replication in vitro and in vivo.

Charlotte Quentin-Froignant, Ann E. Tollefson, Anna Cline-Smith, Sandrine Kappler‐Gratias, Nicolas Landrein, Vincent Roy, Luigi André Agrofoglio, Károly Tóth, Harald Wodrich, Franck Gallardo

This study evaluates LAVR-289, an acyclonucleoside phosphonate, showing potent antiviral activity against adenovirus in vitro and in vivo, with 100% survival in immunocompromised hamsters.

bioRxiv · Feb 20, 2025 · PreprintMicrobiology