Katrin M. Schüle

The paper identifies two regulatory modules that control the sequential transition between early and late gastrulation modes in mouse gastruloids.

The paper investigates the distinct gene-regulatory functions of Eomes and Brachyury in mouse embryos and stem cells, showing Eomes restricts Brachyury activity to ensure proper lineage specification.

The paper identifies EOMES-induced chromatin accessibility as a key step in initiating mesendoderm lineage commitment during mammalian gastrulation.

This paper introduces chimeric 3D-gastruloids as a tool to study mammalian peri-gastrulation development by combining genetically distinct cells to investigate gene function and phenotypes.