Hiroshi Handa

The paper identifies Jade1 as a cofactor of Oct4 that selectively interacts with specific DNA configurations to enhance histone acetylation and transcriptional regulation.

The paper identifies large spinal motor neurons as highly autophagic and shows that their enhanced degradation is neuroprotective in ALS.

This study shows that TDP-43 overexpression reduces excitability of spinal motor neurons during fictive locomotion in zebrafish.

This study uses optogenetic tools to show that TDP-43 oligomerization in zebrafish motor neurons leads to both acute and long-term ALS-related pathologies.