Nathaniel A. Dyment

This study shows that denervation in neonatal mice impairs musculoskeletal growth, altering cell proliferation and mechanotransduction gene programs in tendons and muscles.

This study shows that altering synovial cell mechanotransduction drives OA-like disease without joint injury, with partial effects on symptoms versus structural damage.

This study uses FLARE-ExM to examine changes in tendon cellular and extracellular structures under healthy and perturbed conditions, revealing structural alterations in response to mechanical stress.

This study identifies age-dependent chromatin remodeling in tendon cells that enhances inflammatory responses and contributes to tendon degeneration.

This study shows maternal exercise rescues skeletal defects in fetal akinesia by directly stimulating fetal joint and bone development through mechanical forces.

This study identifies YAP and TAZ as regulators of periosteal expansion during fracture repair, showing their role in cell proliferation and BMP4 regulation.

This paper identifies Prg4+ fibro-adipogenic progenitors in muscle as critical for bone fracture repair by transforming into bone cells and promoting healing.

This study examines mechanical forces during murine tendon development, finding that increased movement correlates with upregulation of Scx and Tnmd.

This study shows YAP and TAZ regulate osteoblast precursor mobilization and angiogenesis during bone development, linking mechanical cues to vascular and bone formation.

This study tracks meniscus maturation in mice, showing that specialized cellular and matrix features emerge before birth and are refined during postnatal growth.

This study shows that Rcn3 regulates collagen modification and fibrillogenesis in postnatal tendon development, affecting tendon structure and mechanical properties.