The paper identifies three urinary biomarkers for clear cell renal cell carcinoma using multi-omics analysis and develops a diagnostic score with 96% accuracy.

EMBO Molecular Medicine · Aug 11, 2026Peer-reviewedCancer Biology

CLEC18A interacts with sulfated GAGs and controls clear cell renal cell carcinoma progression

Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren E. Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef Martin Penninger

This study identifies CLEC18A as a regulator of clear cell renal cell carcinoma progression by interacting with sulfated GAGs and shows its expression is linked to improved patient survival.

FEBS Journal · Aug 23, 2025Peer-reviewedCancer Biology

Fate and state transitions during human blood vessel organoid development

Marina Tsvetomilova Nikolova, Zhisong He, Makiko Seimiya, Gustav Jonsson, Wuji Cao, Ryo Okuda, Reiner Wimmer, Ryoko Okamoto, Jonas M. Nikoloff, Petra Stephanie Dittrich, Josef Martin Penninger, J. Gray Camp, Barbara Treutlein

This study maps the cell state transitions during human blood vessel organoid development using single-cell transcriptomics and identifies key regulators and disease associations.

Cell · Apr 17, 2025Peer-reviewedDevelopmental Biology

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites

David Hoffmann, Stefan Mereiter, Yoo Jin Oh, Vanessa Monteil, Elizabeth Elder, Rong Zhu, Daniel Canena, Lisa Hain, Elisabeth Laurent, Clemens Grünwald‐Gruber, Miriam Klausberger, Gustav Jonsson, Max J. Kellner, Maria Novatchkova, Melita Ticevic, , Josef Martin Penninger

The paper identifies two lectins, Clec4g and CD209c, that bind to conserved glycosylation sites on SARS-CoV-2 Spike and reduce viral infections.

The EMBO Journal · Aug 10, 2021Peer-reviewedMolecular Biology