The paper identifies three urinary biomarkers for clear cell renal cell carcinoma using multi-omics analysis and develops a diagnostic score with 96% accuracy.

EMBO Molecular Medicine · Aug 11, 2026Peer-reviewedCancer Biology

CLEC18A interacts with sulfated GAGs and controls clear cell renal cell carcinoma progression

Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren E. Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef Martin Penninger

This study identifies CLEC18A as a regulator of clear cell renal cell carcinoma progression by interacting with sulfated GAGs and shows its expression is linked to improved patient survival.

FEBS Journal · Aug 23, 2025Peer-reviewedCancer Biology

Metabolic mapping of the human solute carrier superfamily

Tabea Wiedmer, Shao Thing Teoh, Eirini Christodoulaki, Gernot Wolf, Chengzhe Tian, Vitaly Sedlyarov, Abigail P Jarret, Philipp Leippe, Fabian Frommelt, Álvaro Inglés‐Prieto, Sabrina Lindinger, Bárbara M. G. Barbosa, Svenja Onstein, Christoph Klimek, Julio Garcia Murias, , Giulio Superti‐Furga

The paper systematically evaluates the metabolic and transcriptional effects of SLC superfamily members, identifying new substrates and functional groups.

Molecular Systems Biology · May 12, 2025Peer-reviewedSystems Biology

Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants

Vanessa Monteil, Brett Eaton, Elena N. Postnikova, Michael J. Murphy, Benedict Braunsfeld, Ian Crozier, Franz Kricek, Janine Niederhöfer, Alice Schwarzböck, Helene Breid, Stéphanie Devignot, Jonas Klingström, Charlotte Thålin, Max J. Kellner, Wanda Christ, , Josef Martin Penninger

This paper shows that clinical-grade soluble ACE2 effectively inhibits multiple SARS-CoV-2 variants, including VOCs, in cell cultures and across independent labs.

EMBO Molecular Medicine · Jul 4, 2022Peer-reviewedMolecular Biology

Clinical grade ACE2 effectively inhibits SARS-CoV-2 Omicron infections

Vanessa Monteil, Stéphanie Devignot, Jonas Klingström, Charlotte Thålin, Max J. Kellner, Wanda Christ, Sebastian Havervall, Stefan Mereiter, Sylvia Knapp, Núria Montserrat, Benedict Braunsfeld, I. Kozieradzki, Omar Hasan Ali, Astrid Hagelkrüys, Johannes Stadlmann, , Alì Mirazimi

The paper shows clinical grade recombinant ACE2 effectively neutralizes SARS-CoV-2 Omicron in VeroE6 cells, outperforming neutralization against reference isolates.

bioRxiv · Dec 25, 2021 · PreprintMolecular Biology

FIBCD1 is a Conserved Receptor for Chondroitin Sulphate Proteoglycans of the Brain Extracellular Matrix and a Candidate Gene for a Complex Neurodevelopmental Disorder

Christopher W. Fell, Astrid Hagelkrüys, Ana Cicvaric, Marion Horrer, Lucy Liu, Joshua Shing Shun Li, Johannes Stadlmann, Anton A. Polyansky, Stefan Mereiter, Miguel Angel Tejada, Tomislav Kokotović, Angelica Scaramuzza, Kimberly A. Twyman, Michelle M. Morrow, Jane Juusola, , Vanja Nagy

This study identifies FIBCD1 as a conserved receptor for chondroitin sulphate proteoglycans in the brain ECM, linking it to neurodevelopmental disorders through genetic and functional analyses.

bioRxiv · Sep 9, 2021 · PreprintNeuroscience

Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites

David Hoffmann, Stefan Mereiter, Yoo Jin Oh, Vanessa Monteil, Elizabeth Elder, Rong Zhu, Daniel Canena, Lisa Hain, Elisabeth Laurent, Clemens Grünwald‐Gruber, Miriam Klausberger, Gustav Jonsson, Max J. Kellner, Maria Novatchkova, Melita Ticevic, , Josef Martin Penninger

The paper identifies two lectins, Clec4g and CD209c, that bind to conserved glycosylation sites on SARS-CoV-2 Spike and reduce viral infections.

The EMBO Journal · Aug 10, 2021Peer-reviewedMolecular Biology