Joel H. Graber

The paper identifies eight new genes involved in zebrafish glomerular development through transcriptome analysis and CRISPR-Cas9 screening, linking them to proteinuria and glomerular leakage.

The paper introduces a tissue-clearing framework and mesoSPIM-ultra system for large-scale single-neuron tracing in cleared mouse tissue.

This study identifies mesenchymal-derived neural progenitors that transdifferentiate into retinal ganglion cells in zebrafish after neuronal ablation, revealing a novel mechanism for retinal regeneration.

The paper refines gene annotations in Gryllus bimaculatus using RNAseq data and identifies differentially expressed genes related to injury response and neuroplasticity.

This paper develops and compares two cell-ablation systems in axolotls to study macrophage roles in regeneration, finding macrophages are essential for skeletal and nervous system repair.

This study shows that intermittent fasting improves muscle health and extends lifespan in both sexes of African turquoise killifish, with sex-specific molecular and cellular changes.

The paper develops a zebrafish model of accelerated muscle atrophy by inducing Atrogin-1 expression, showing muscle degeneration, locomotion dysfunction, and neurodegenerative effects.

This paper shows that SGLT2 inhibition reduces age-related vascular rarefaction and preserves renal function in African turquoise killifish.

This study shows that glucocorticoid and mineralocorticoid receptors promote vascular development in kidney organoids through endothelial cell differentiation and vessel formation.

This study shows connective-tissue cells are essential for axolotl limb regeneration, making up 75% of blastema cells and requiring specific signaling for regeneration.

This study identifies ML233 as a potent and safe tyrosinase inhibitor that reduces melanin production in zebrafish and murine melanoma cells without significant toxicity.

The paper shows that vertebral segmentation during axolotl tail regeneration occurs via a buckling instability mechanism, distinct from the somite-based process in embryonic development.

This study shows that macrophage differentiation involves changes in mRNA polyadenylation, poly(A) site usage, and sensitivity to CstF64, a cleavage/polyadenylation protein.

The paper investigates how RASA3 mutations affect hematopoiesis, showing that genetic background and molecular variant significantly influence disease outcomes in mouse models.

The paper identifies Klf9 as a key regulator of the transcriptomic response to glucocorticoid receptor activity in zebrafish larvae, showing it mediates proinflammatory gene upregulation under chronic cortisol exposure.

The paper develops bioinformatics workflows to analyze genomic data from patient-derived xenografts, addressing challenges like separating mouse and human reads and identifying somatic mutations without paired normal DNA.

The paper introduces a reference trait analysis method to correlate complex traits with molecular features in disjoint samples, showing it outperforms TWAS in identifying associated transcripts.