Pavel Artemov

The paper shows that immune surveillance in germinal centers eliminates premalignant B-cells, but lymphoma-like mutations allow immune escape and progression to lymphoma.

This study reveals a unique 3D genome architecture in premeiotic gonadal germ cells, linked to epigenetic reprogramming and loss of TADs, alongside DNA demethylation.

The paper identifies trimodal QTLs that jointly affect enhancer accessibility, promoter contacts, and gene expression in monocytes, revealing genetic links between enhancer activity and chromatin boundaries.

The paper maps promoter interactions in human ILC3s using PCHi-C and links GWAS risk variants to target genes, identifying new autoimmune disease risk genes.

This study shows that high dropout rates in scRNA-seq hinder alternative splicing analysis, while low isoform quantification errors in mice reduce this obstacle.