Monica Della Rosa

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency

The paper investigates the chromosomal contacts of poised enhancers during the transition from naive to primed human pluripotency, revealing their dynamics and functional significance.

Shared and distinct molecular effects of regulatory genetic variants provide insight into mechanisms of distal enhancer-promoter communication

The paper identifies trimodal QTLs that jointly affect enhancer accessibility, promoter contacts, and gene expression in monocytes, revealing genetic links between enhancer activity and chromatin boundaries.

High-resolution promoter interaction analysis implicates genes involved in the activation of Type 3 Innate Lymphoid Cells in autoimmune disease risk

The paper maps promoter interactions in human ILC3s using PCHi-C and links GWAS risk variants to target genes, identifying new autoimmune disease risk genes.

Tri-methylation of Histone H3 Lysine 4 Facilitates Gene Expression in Ageing Cells

This study shows that H3K4me3 is essential for maintaining normal gene expression levels across yeast lifespan, with COMPASS mutations reducing lifespan and causing gene expression defects.