Fitness and immune-escape within germinal centers shape premalignant evolution toward lymphoma
Lingling Zhang, Miu Shing Hung, Oscar Atkins, Pavel Artemov, Akhésa Sochon, Victoire Boulat, Hamid Kashkar, Hans Christian Reinhardt, Jude Fitzgibbon, Jessica Okosun, Dinis Pedro Calado
The paper shows that immune surveillance in germinal centers eliminates premalignant B-cells, but lymphoma-like mutations allow immune escape and progression to lymphoma.
bioRxiv · Jun 26, 2026 · PreprintCancer Biology