Author

Raghavendra Upadhya

Texas A&M Health Science CenterORCID 0000-0001-6741-6308Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Ashok Kumar ShettyiD· 3 shared Leelavathi Narayana MadhuiD· 3 shared Shama Rao· 3 shared Bing Shuai· 2 shared Goutham ShankariD· 2 shared James J. CaiiD· 2 shared Maheedhar KodaliiD· 2 shared Sahithi Attaluri· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersNeuroscience

Ashok Kumar ShettyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

NeuroscienceStem Cell Research & TherapyPeer-reviewedApr 18, 2025

Extracellular Vesicles from hiPSC-derived NSCs Protect Human Neurons against Abeta-42 Oligomers Induced Neurodegeneration, Mitochondrial Dysfunction and Tau Phosphorylation

Shama Rao, Leelavathi Narayana Madhu, Roshni Sara Babu…·Ashok Kumar Shetty

This study shows that extracellular vesicles from hiPSC-derived neural stem cells protect human neurons from Aβ-42 oligomer-induced neurodegeneration, mitochondrial dysfunction, and tau phosphorylation.

18 citationstop 1%

humanstatistical model

𝕏 PostBluesky

NeurosciencebioRxivPreprintMar 2, 2025

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signaling, in Aged Hippocampus

Leelavathi Narayana Madhu, Maheedhar Kodali, Shama Rao…·Ashok Kumar Shetty

This study shows that intranasal hiPSC-NSC-EVs reduce neuroinflammaging in aged mice by modulating microglial transcriptome and signaling pathways.

DOI 10.1101/2025.03.02.641082

mousebulk RNA-seq

𝕏 PostBluesky

NeuroscienceJournal of Extracellular VesiclesPeer-reviewedNov 1, 2024

Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer's Model

Leelavathi Narayana Madhu, Maheedhar Kodali, Raghavendra Upadhya…·Ashok Kumar Shetty

This study shows that intranasally administered EVs from hiPSC-derived NSCs reduce microglial activation and improve brain function in an Alzheimer's model.

66 citationstop 1%

mousebulk RNA-seq

𝕏 PostBluesky