Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signaling, in Aged Hippocampus
Leelavathi Narayana Madhu, Maheedhar Kodali, Shama Rao, Sahithi Attaluri, Raghavendra Upadhya, Goutham Shankar, Bing Shuai, Yogish Somayaji, Shruthi V. Ganesh, Vignesh S. Kumar, Jeswin E. James, Padmashri A Shetty, Avery LeMaire, Xiaolan Rao, James J Cai, Ashok Kumar Shetty
This study shows that intranasal hiPSC-NSC-EVs reduce neuroinflammaging in aged mice by modulating microglial transcriptome and signaling pathways.
bioRxiv · Mar 2, 2025 · PreprintNeuroscience