Shama Rao

Extracellular Vesicles from hiPSC-derived NSCs Protect Human Neurons against Abeta-42 Oligomers Induced Neurodegeneration, Mitochondrial Dysfunction and Tau Phosphorylation

This study shows that extracellular vesicles from hiPSC-derived neural stem cells protect human neurons from Aβ-42 oligomer-induced neurodegeneration, mitochondrial dysfunction, and tau phosphorylation.

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signaling, in Aged Hippocampus

This study shows that intranasal hiPSC-NSC-EVs reduce neuroinflammaging in aged mice by modulating microglial transcriptome and signaling pathways.

Residual Microglia Following Short-term PLX5622 Treatment in 5xFAD Mice Exhibit Diminished NLRP3 Inflammasome and mTOR Signaling, and Enhanced Autophagy

This study examines the effects of short-term CSF1R inhibition in 5xFAD mice, showing reduced microglia, noninflammatory phenotype, and altered signaling pathways without affecting Aβ plaques.

Intranasally Administered EVs from hiPSC-derived NSCs Alter the Transcriptomic Profile of Activated Microglia and Conserve Brain Function in an Alzheimer's Model

This study shows that intranasally administered EVs from hiPSC-derived NSCs reduce microglial activation and improve brain function in an Alzheimer's model.