Jessica A. Hamerman

This study identifies IRF5 as a critical driver of iHPC differentiation and MAS pathogenesis, showing it can be targeted pharmacologically.

The paper identifies a type I IFN-driven monocyte dysregulation and a MAS-associated CD8+ T cell population in macrophage activation syndrome using bulk and single-cell RNA sequencing.

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

This study shows that loss of FLII impairs CD8+ and regulatory T cell function by affecting trafficking and immune regulation.

The paper identifies biomarkers and genetic variants associated with COVID-19 linked secondary hemophagocytic lymphohistiocytosis (sHLH) and links them to immune system defects.