Author

James L. LaBelle

University of ChicagoORCID 0000-0001-6776-4695Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:human· 1

Frequent Co-Authors

Alexander MuiriD· 1 shared Alica K. MichelsiD· 1 shared Anika T. Thomas-TothiD· 1 shared Christopher J. HalbrookiD· 1 shared Christopher R. WeberiD· 1 shared Colin S. SheehaniD· 1 shared Darby AgovinoiD· 1 shared Duy-Thuc NguyeniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Alexander MuirORCID

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2 papers

Recent·Most cited

ImmunologyCancer Immunology ResearchPeer-reviewedMay 8, 2026

Low-Strength Type I Interferon Signaling Promotes CAR T-Cell Treatment Efficacy

Erting Tang, Yifei Hu, Guoshuai Cao…·Jun Huang

This study shows that low-strength type I interferon signaling enhances CAR T-cell efficacy against B-cell lymphoma and leukemia without causing in vivo toxicity.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 4, 2025

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Colin S. Sheehan, Lyndon Hu, Guillaume Cognet…·Alexander Muir

This study shows that pancreatic cancer cells in a nutrient-stressed tumor microenvironment develop drug tolerance, and identifies BCL-XL inhibition as a potential therapeutic strategy.

DOI 10.1101/2025.09.04.673818

mousebulk RNA-seq

𝕏 PostBluesky