Mansour Aboelenain

This study reconstitutes vertebrate meiotic kinetochores to identify conserved factors essential for chromosome segregation in mammalian oocytes.

The paper shows maternal CENP-C restores centromere symmetry in zygotes by asymmetrically recruiting to paternal centromeres, ensuring proper chromosome segregation.

The paper investigates the causes of multi-nucleation in two-cell human embryos and finds that spindle and metaphase plate incoherence during the first mitosis leads to this phenomenon.

The study identifies genetic determinants of reproductive aging linked to egg aneuploidy by analyzing maternal exomes and shows kinesin gene variants contribute to aneuploidy and accelerated aging.

The paper uses ulc-WGS data from PGT-A to identify a genetic locus associated with maternal meiotic aneuploidy risk and validates its function in mouse oocytes.

The paper tracks CENP-A dynamics in mouse gametes and embryos, showing sex-specific differences in centromere maintenance and equalization during early development.