Emmanuelle Buhler

Virus-against-virus dominant-negative interference strategy targeting a viral CC chemokine prevents cytomegalovirus-related neurodevelopmental pathogenesis

This study shows that a dominant-negative mutant of the viral chemokine RCK3 prevents CMV-induced neurodevelopmental disorders in a rat model.

Regulation of Neuronal Chloride Homeostasis by Pro- and Mature Brain-Derived Neurotrophic Factor (BDNF) via KCC2 Cation-Chloride Cotransporters in Rat Cortical Neurons

This study investigates how pro- and mature BDNF regulate chloride homeostasis via KCC2 in rat neurons, showing their distinct roles in inhibitory neurotransmission and developmental behavior.

Pathogenic MTOR somatic variant causing focal cortical dysplasia drives hyperexcitability via overactivation of neuronal GluN2C NMDA receptors

This study shows that a somatic MTOR variant in FCD type II causes hyperexcitability through overactivation of GluN2C NMDA receptors in rat neurons.

Early suppression of excitability in subcortical band heterotopia modifies epileptogenesis in rats

This study investigates how early suppression of neuronal excitability in a rat model of subcortical band heterotopia affects epileptogenesis and seizure progression.

Smoothened receptor Signaling regulates the developmental shift of GABA polarity in rat somatosensory cortex

This study shows that Smo signaling regulates the shift of GABA polarity in rat somatosensory cortex by controlling KCC2 stability and chloride homeostasis.

Correct laminar positioning in the neocortex influences proper dendritic and synaptic development

This study shows that laminar positioning of cortical neurons affects dendritic and synaptic development, with misplaced neurons showing severe defects in dendrite and synapse formation.