Author

Tomáš Cihlář

Gilead Sciences (United States)ORCID 0000-0001-6840-0885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:non-human primate· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Jason K. PerryiD· 3 shared Arya VijjapurapuiD· 2 shared Dustin S. SiegeliD· 2 shared Hongmei Mo· 2 shared Jared PittsiD· 2 shared John P. BilelloiD· 2 shared Meghan S. VermillioniD· 2 shared Nicholas C. RiolaiD· 2 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Jason K. PerryORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologyNature CommunicationsPeer-reviewedJul 11, 2025

Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys

Jared Pitts, J. Lizbeth Reyes Zamora, Savrina Manhas…·John P. Bilello

This study shows that oral obeldesivir is effective against RSV infection in African green monkeys, reducing viral load significantly.

7 citationstop 4%

non-human primateexperimental assay

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BiochemistryJournal of Medicinal ChemistryPeer-reviewedJul 17, 2024

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

Dustin S. Siegel, Hon C. Hui, Jared Pitts…·Richard L. Mackman

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

17 citationstop 4%

non-human primateexperimental assay

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GenomicsAntiviral ResearchPeer-reviewedFeb 6, 2021

Genetic Conservation of SARS-CoV-2 RNA Replication Complex in Globally Circulating Isolates and Recently Emerged Variants from Humans and Minks Suggests Minimal Pre-Existing Resistance to Remdesivir

Ross Martin, Jiani Li, Aiyappa Parvangada…·Evguenia S. Svarovskaia

The paper analyzes genetic diversity in SARS-CoV-2 RNA replication complex across global isolates and variants, finding minimal pre-existing resistance to remdesivir.

48 citations

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