Jeremy C. M. Teo

This study shows that substrate mechanics can enhance CD8+ T cell persistence and anti-tumor activity by preserving metabolic fitness and cytokine balance during expansion.

This paper evaluates how different molecular weights of tyramine-modified hyaluronan affect the polarization of THP-1 and PBMCs-derived macrophages, showing LMW THA drives M1-like polarization while HMW THA induces a mixed profile.

This study shows that dense and aligned collagen matrices suppress T-cell activation via YAP signaling, suggesting ways to improve immunotherapy by modulating T-cell responses in such environments.

This study shows that stiffening the tumor microenvironment via collagen alignment and crosslinking promotes M2 macrophage polarization, enhances immune suppression, and supports cancer cell growth.

This paper shows that As3mt regulates hepatic energy metabolism independently of arsenic detoxification, leading to mitochondrial dysfunction and fatty liver in zebrafish mutants.