Gaurav D. Gaiha

Effector-primed TCF1+ CD8+ T cells elicited by a networked epitope vaccine stratify protection against SHIV acquisition

This study identifies an effector-primed TCF1+ CD8+ T cell state linked to delayed SHIV acquisition and reduced viral load in vaccinated non-human primates.

NK-like and networked CD8+ T cell immunity mediates exceptional HIV control

The paper identifies an NK-like KIR CD8 T cell subset as a key feature of exceptional HIV control, complementing networked epitope targeting for immunotherapeutic strategies.

CD8 T cells with classical and NK-like cytotoxic gene expression programs mediate control of HBV replication and functional cure

The paper identifies two distinct CD8 T cell gene expression programs in HBV infection that correlate with viral control and functional cure.

Non-clinical safety of GRAd vector-based COVID-19 and HIV vaccines supports a platform regulatory approach

This study evaluates the non-clinical safety of two GRAd vector-based vaccines for COVID-19 and HIV, showing consistent safety profiles and supporting a regulatory platform approach.

Duration of Initial Viremia Modulates Functional Properties of HIV-specific T Cell Receptors

This study examines how the duration of initial HIV-1 viremia affects the functional properties of HIV-specific T cell receptors in individuals with HLA-B*58:01.

Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection