Stephanie J. Grainger

This study identifies Dishevelled 2 as a regulator of HSC specification in zebrafish by coordinating Notch signaling and immune cell support during the endothelial-to-hematopoietic transition.

This study identifies kainate receptors' role in coordinating primitive hematopoiesis and hemogenic niche organization in zebrafish, showing their impact on hematopoietic stem cell development through endothelial Notch signaling.

The paper describes a zebrafish model of NAD+ deficiency to study congenital anomalies and their potential link to VACTERL association.

The paper shows Sfrp1a regulates zebrafish HSPC development and differentiation in a dose-dependent manner, with loss or gain of function affecting HSPC numbers and lineage differentiation.

The paper identifies Trip12 as an E3 ubiquitin ligase that ubiquitinates Fzd9b, reducing its availability and Wnt9a/Fzd9b signaling in zebrafish hematopoietic stem cells.

This study shows that endothelial Piezo1 regulates vascular smooth muscle cell differentiation in zebrafish and mice by modulating klf2a levels and flow force sensing.

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

The paper shows EGFR is required for Wnt9a-Fzd9b signaling specificity in HSPC development, identifying key domains and phosphorylation events.