Author

Zeynep Ergün

Johannes Gutenberg University Mainz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Approach:genetic perturbation / CRISPR· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

Ari WaismaniD· 3 shared Aysan Poursadegh Zonouzi· 2 shared Emmanouil StylianakisiD· 2 shared Nadine HövelmeyeriD· 2 shared Ana-Marija Kulis-Mandic· 1 shared Anne Hausen· 1 shared Antonia KolbiD· 1 shared Berenice FischeriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

Ari WaismanORCID

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3 papers

Recent·Most cited

Targeting soluble immunoglobulins ameliorates idiopathic multicentric Castleman disease in a mouse model

David C. Uhlfelder, David Andruszewski, Leon R Amelong, Helena S Schafer, Mia Huttenschmidt, Michaela Blanfeld, Carsten Schelmbauer, Zeynep Ergün, Aysan Poursadegh Zonouzi, Anne Hausen, S. Zimmer, Matthias M. Gaida, Saskia von Ungern-Sternberg, Kerstin Jurk, Frank Thomas Wunderlich, , Ilgiz A. Mufazalov

This paper develops a mouse model of idiopathic multicentric Castleman disease (iMCD) by targeting IL-6 to Foxp3+ Treg cells, showing that reducing soluble immunoglobulin production alleviates disease symptoms and improves survival.

bioRxiv · Jul 29, 2026 · PreprintImmunology

Treg-derived IκBζ promotes their conversion into Th2-like effectors and drives type 2 inflammation via BATF

Tanja Kübelbeck, Ana-Marija Kulis-Mandic, Antonia Kolb, Emmanouil Stylianakis, Zeynep Ergün, Delia Mihaela Mihoc, Sara Salome Helbich, Kartikeya Singh, Matthias Klein, Niklas Beumer, Berenice Fischer, Stephan Hailfinger, Klaus Schulze‐Osthoff, Ari Waisman, Michael Delacher, , Daniela Kramer

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

bioRxiv · Feb 24, 2026 · PreprintImmunology

Aging-Associated Microbiota Drives Treg Dysfunction via TNF Signaling

Jefferson Antônio Leite, Zeynep Ergün, Emmanouil Stylianakis, Rebecca Jasser, Florian Ingelfinger, Natalia Notarberardino Bos, Aysan Poursadegh Zonouzi, Michal Mark, Katlynn Carter, Xinyuan Liu, Nadine Hövelmeyer, Tommy Regen, Manolis Pasparakis, Christian Neumann, Ido Amit, , Ari Waisman

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.

bioRxiv · Aug 8, 2025 · PreprintImmunology