Ido Amit

This study identifies how SALL1 and neural microenvironmental context shape the identity of stem cell-derived human microglia-like cells in 2D and 3D cultures.

This study develops PD-1-targeted CAR-T cells that specifically eliminate synovium-associated T cells and reduce arthritis in experimental models.

This study engineers CAR T cells to promote tissue repair in CNS injury by modulating immune responses and reducing inflammation.

The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

CytoVI is a deep generative model for antibody-based single cell technologies that improves integration, imputation, and analysis across different platforms and antibody panels.

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.

This study identifies a p53 mutation-specific immunotherapy strategy for ovarian cancer by targeting AREG and PD-L1, showing efficacy in mouse models and patient-derived organoids.

The paper shows that T cell-derived IFN-γ suppresses TFH differentiation and antibody responses by acting through dendritic cells, not directly on CD4+ T cells.

This study shows that TMPRSS2-ERG fusion promotes resistance to antiandrogens by interacting with GR, suggesting combined GR and AR inhibition could benefit tERG-positive prostate cancer patients.

The paper identifies TGF-β signaling as a regulator of natural killer cell function in both pregnancy and tumor progression by analyzing immune compartment dynamics in human and mouse models.

The paper examines circadian gene expression in microglia across health and Huntington's disease, finding disrupted rhythms in symptomatic mice.

This study compares four rejuvenation strategies in mice and identifies a shared gene expression program involving reduced inflammation and restored fatty acid metabolism, suggesting inflammation as a key upstream factor in aging.

This study shows that neural plate progenitors contribute to both anterior and posterior pituitary cells in zebrafish and mouse, challenging the traditional view of pituitary cell origins.

The paper introduces PIC-seq to study cell-cell contact-specific gene expression during mouse embryonic development and identifies novel gene expression signatures dependent on neighboring cell types.

The paper identifies two distinct gene programs associated with disease tolerance and resistance in influenza virus infection using mouse strain data.

This study creates a spatiotemporally resolved single-cell atlas of Plasmodium liver stage infection, revealing zone-specific parasite gene expression and immune responses in hepatocytes.

The paper uses single-cell RNA sequencing to study mouse limb development, identifying progenitor states and their differentiation into skeletal elements in a spatiotemporal pattern.

The paper introduces DestVI, a method for multi-resolution spatial transcriptomics analysis that captures continuous cell state variation, and applies it to study inflammation in lymph nodes and tumors.

The paper identifies bi-fated tendon-to-bone attachment cells regulated by shared enhancers and KLF transcription factors, revealing how these cells integrate chondrocyte and tenocyte features.

The paper identifies unique transcriptional signatures in the mouse brain that represent distinct salient experiences and their affective attributes.

This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.

The paper proposes the Human Cell Atlas project to catalog all human cell types through molecular profiling and connects this data with classical cellular descriptions.