Emmanouil Stylianakis

OTUB1 controls marginal zone B-cell development by stabilizing RelA in a CD40-dependent manner

This study shows OTUB1 stabilizes RelA by preventing its ubiquitination and degradation, which is crucial for controlling marginal zone B-cell development through CD40-dependent NF-κB signaling.

Prohibitin 2 is a Key Regulator of T Cell Proliferation, Differentiation, and Effector Functions in vivo

This study investigates the role of PHB2 in T cell proliferation, differentiation, and effector functions, finding that PHB2 deficiency causes cell cycle arrest and metabolic dysfunction.

A streamlined spectral cytometry method for FAD and NADH autofluorescence analysis in immunometabolic studies

The paper introduces a streamlined spectral cytometry method to analyze NADH and FAD autofluorescence in immune cells, demonstrating its application in assessing metabolic states of splenic B-cell subsets.

Treg-derived IκBζ promotes their conversion into Th2-like effectors and drives type 2 inflammation via BATF

This study identifies IκBζ as a key regulator of Treg cell plasticity, showing it drives their conversion into Th2-like effectors and promotes type 2 inflammation.

B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the anti-viral CD8+ T cell response

This study shows B cells sustain Langerin+ cDC1s via LTβ and MMMs to support anti-viral CD8+ T cell responses during MCMV infection.

Aging-Associated Microbiota Drives Treg Dysfunction via TNF Signaling

This study shows that aging microbiota impairs Treg cell function through TNF signaling, leading to inflammation and immune aging.

The human SKI complex prevents DNA-RNA hybrid-associated telomere instability

This study shows the human SKI complex prevents telomere instability by resolving DNA-RNA hybrids at telomeres during G2 phase.