Kate M. Van Pelt

This study shows that loss of FICD rescues motor impairments and reverses oligodendrocyte maturation deficits in a SCA3 mouse model by restoring ER homeostasis and myelination.

This study shows that loss of FIC-1-mediated AMPylation activates the UPRER and increases cytosolic HSP70 chaperones, which reduces polyglutamine toxicity in C. elegans.

This study shows how two HSP70 chaperones in C. elegans, HSP-3 and HSP-4, have distinct and overlapping roles in ER proteostasis, affecting growth, reproduction, stress resistance, aging, and ER-Phagy.