Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.
Anand Suresh, Nazim Kourdougli, Toshihiro Nomura…·Carlos Portera‐Cailliau
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CHU Sainte-Justine Research CenterORCID 0000-0001-6932-874XUnclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
5 papers
Recent·Most cited
Anand Suresh, Nazim Kourdougli, Toshihiro Nomura…·Carlos Portera‐Cailliau
Diana E. Mitchell, Soledad Miranda‐Rottmann, Maxime G. Blanchard, Roberto Araya
This study investigates synaptic integration in a mouse model of Fragile X Syndrome and finds sublinear summation of excitatory inputs in layer 5 pyramidal neurons, suggesting altered sensory and predictive input processing in ASD.
Sabrina Tazerart, Maxime G. Blanchard, Soledad Miranda‐Rottmann…·Roberto Araya
The paper shows that BK channels in small-headed dendritic spines reduce EPSP amplitude and enhance calcium signals, suggesting a role in synaptic regulation.
Dimitri Ryczko, Maroua Hanini‐Daoud, Steven Condamine…·Arlette Kolta
This study shows astrocytes modulate layer 5 pyramidal neuron firing in the mouse visual cortex through S100β-mediated changes in extracellular calcium and Nav1.6 channel activation.
Sabrina Tazerart, Diana E. Mitchell, Soledad Miranda‐Rottmann, Roberto Araya
The paper investigates spike-timing-dependent plasticity (STDP) in dendritic spines, showing that clustered spines enhance LTP while suppressing LTD.