Glauco P. Tocchini‐Valentini

A resource of targeted mutant mouse lines for 5,061 genes

The paper reports the generation of over 5,000 new mouse mutant strains for targeted genes, significantly expanding the available genetic resources for biomedical research.

Human and mouse essentiality screens as a resource for disease gene discovery

The paper integrates gene essentiality data from human and mouse screens to classify genes into FUSIL categories, identifying developmental lethal genes associated with rare diseases.

X-ray 3D imaging of gene expression in whole-mount murine brain by microCT, implication for functional analysis of tRNA endonuclease 54 gene mutated in pontocerebellar hypoplasia.

The paper introduces an X-ray-based method for 3D gene expression analysis in whole-mount murine brains, demonstrating Tsen54 gene expression patterns in key brain regions relevant to motor and memory functions.

Soft Windowing Application to Improve Analysis of High-throughput Phenotyping Data

The paper introduces a method called soft windowing to improve analysis of high-throughput phenotyping data by reducing false positives and increasing significant results.