The Muscle Tissue Environment Limits Muscle Stem Cells in Aged Mice
Alicia Ann Cutler, Tenaya K. Vallery, Thomas Orion Vogler, Jesse V. Kurland, Thea S. Zlatkov, Tiffany L. Antwine, Nicole Dalla Betta, Tze-Ling Chang, Bradley T. Pawlikowski, Carson H. Butcher, Kory J. Lavine, David M. Ornitz, Kristi S. Anseth, Bradley B. Olwin
This study shows that the aged muscle tissue environment limits muscle stem cell function, and combined interventions can partially restore muscle mass in aged mice.
bioRxiv · Apr 13, 2026 · PreprintCell Biology