Jean‐Paul Soucy

This study links higher hippocampal 18F-MK6240 uptake in TLE to increased seizure burden, altered NREM sleep microstructure, and impaired memory.

The paper presents an open dataset of cerebral tau deposition in young healthy adults using [18F]MK6240 PET to support imaging biomarker studies in non-geriatric populations.

The paper examines how changes in functional connectivity during rest and task relate to Alzheimer's pathology and episodic memory in older adults.

The paper shows that cholinergic synaptic plasticity, specifically VAChT responses to tau, correlates with cognitive resilience in presymptomatic AD.

This study finds increased tau deposition in TLE patients using PET imaging, linked to cognitive impairment and brain connectivity patterns.

The paper determines the cryo-EM structure of Alzheimer's disease tau filaments bound by the PET ligand MK-6240, revealing key binding interactions that inform ligand design.

This study examines the relationship between amyloid-PET signals in white matter and microstructural changes like free water and fiber integrity, finding that free water and WMH volume are more closely linked to Aβ-PET in WMH regions.

Neurotransmitter receptor/transporter PET maps (19 targets, 1239 healthy participants) align with connectomes, explain MEG power, and track cognitive gradients and cortical thinning in 13 disorders.