Author

Shing Fai Chan

Indiana University IndianapolisORCID 0000-0001-6988-4631Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Approach:experimental assay· 1

Frequent Co-Authors

Abdullah SultaniD· 1 shared Agnes Pui-Yee ChaniD· 1 shared Ardan Muammer SaguneriD· 1 shared Chuanyu Wei· 1 shared Clare Bakker· 1 shared Corinna Brunckhorst· 1 shared Cynthia A. JamesiD· 1 shared Daniel H. GeschwindiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Abdullah SultanORCID

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2 papers

Recent·Most cited

Cell BiologyCirculation ResearchPeer-reviewedAug 19, 2026

Desmoplakin mutations in cardiac fibroblasts cause TGF?1-mediated pathological fibrogenesis in desmoplakin cardiomyopathy via beclin-1 regulation

Chuanyu Wei, Shing Fai Chan, Ardan Muammer Saguner…·Huei-Sheng Vincent Chen

This study shows that DSP mutations in cardiac fibroblasts enhance TGFβ1-induced fibrosis by disrupting beclin-1 regulation and autophagy, leading to excessive collagen accumulation and fibrotic gene activation.

DOI 10.1161/circresaha.124.325512

humanbulk RNA-seq

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NeuroscienceMolecular PsychiatryPeer-reviewedSep 30, 2024

Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids

Dorit Trudler, Swagata Ghatak, Michael Bula…·Stuart A. Lipton

Autism-like MEF2C+/- patient hiPSC models show miRNA-mediated overproduction of astrocytes and hyperactivity of neurons.

20 citationstop 3%

humanbulk RNA-seq

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