Author

Michael Bula

Scripps Research InstituteORCID 0000-0002-2164-0619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1

Frequent Co-Authors

Dorit TrudleriD· 2 shared Maria V. TalantovaiD· 2 shared Nicholas J. SchorkiD· 2 shared Nima Dolatabadi· 2 shared Sergio R. LabraiD· 2 shared Stuart A. LiptoniD· 2 shared Swagata GhatakiD· 2 shared Abdullah SultaniD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Dorit TrudlerORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Autophagy activators normalize aberrant Tau proteostasis and rescue synapses in human familial Alzheimer's disease iPSC-derived cortical organoids

Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria V. Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, , Stuart A. Lipton

This study uses human iPSC-derived cortical organoids to model familial Alzheimer's disease and shows that autophagy activators reduce pathological Tau and Aβ accumulation and rescue synaptic loss.

Advanced Science · Jan 27, 2026Peer-reviewedNeuroscience

Aberrant gliogenesis and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids

Dorit Trudler, Swagata Ghatak, Michael Bula, James Parker, Maria V. Talantova, Melissa Luevanos, Sergio R. Labra, Titas Grabauskas, Sarah Moore Noveral, Mayu Teranaka, Emily Schahrer, Nima Dolatabadi, Clare Bakker, Kevin M. Lopez, Abdullah Sultan, , Stuart A. Lipton

Autism-like MEF2C+/- patient hiPSC models show miRNA-mediated overproduction of astrocytes and hyperactivity of neurons.

Molecular Psychiatry · Sep 30, 2024Peer-reviewedNeuroscience

A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes

Jinsoo Seo, Ping‐Chieh Pao, Oleg Kritskiy, Audrey Lee, Debasis Patnaik, Lauren Ashley Watson, Michael Bula, Scarlett J. Barker, Jay Penney, M. Catarina Silva, Stephen J. Haggarty, Li‐Huei Tsai

The paper identifies a Cdk5-derived peptide that inhibits Cdk5/p25 activity and reduces neurodegenerative phenotypes in cellular and animal models.

bioRxiv · May 12, 2020 · PreprintNeuroscience