Ian David Blum

This study investigates the effects of brain-specific noradrenergic depletion on behavior and gene expression, finding anxiolytic effects and altered gene regulation in vulnerable brain regions.

The paper shows that astroglial calcium signaling in Drosophila increases with sleep need and is required for homeostatic sleep rebound, identifying TyrRII as a key receptor involved in this process.

This study identifies a conserved clock-regulated neural network in mice and Drosophila that controls arousal and sleep, showing that mWake+ cells are critical for circadian-dependent neural excitability.