Mark N. Wu

Sleep pressure is differentially regulated by molecularly distinct subtypes of Lhx6-positive and Lhx6-negative neurons of the zona incerta.

An Amygdalar Oscillator Coordinates Cellular and Behavioral Rhythms

The paper identifies an extra-SCN brain oscillator in the lateral amygdala that coordinates cellular and behavioral rhythms through mWAKE/ANKFN1 expression.

A subclass of evening cells promotes the switch from arousal to sleep at dusk

This study identifies E1 neurons in Drosophila that regulate the transition from arousal to sleep at dusk through light-dependent mechanisms.

FlyVISTA, an Integrated Machine Learning Platformfor Deep Phenotyping of Sleep in Drosophila

FlyVISTA is a machine learning platform that identifies sleep-associated microbehaviors in Drosophila by analyzing high-resolution video data and annotating body parts.

Astroglial Calcium Signaling Encodes Sleep Need in Drosophila

The paper shows that astroglial calcium signaling in Drosophila increases with sleep need and is required for homeostatic sleep rebound, identifying TyrRII as a key receptor involved in this process.

Characterization of mWake expression in the murine brain

The paper characterizes mWake expression in the adult mouse brain, identifying its presence in neurons and non-neuronal cells across multiple brain regions and providing single-cell RNA sequencing analysis of hypothalamic mWake+ cells.

A Clock-Driven Neural Network Critical for Arousal

This study identifies a conserved clock-regulated neural network in mice and Drosophila that controls arousal and sleep, showing that mWake+ cells are critical for circadian-dependent neural excitability.

Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay

The paper identifies a circadian pathway in Drosophila where morning and evening oscillators drive pre-motor centers via specific dopaminergic neurons, resulting in a two-peak locomotor activity pattern.