This study investigates sex-dependent cross-resilience to social defeat and learned helplessness stress models, revealing sex-specific molecular and behavioral patterns linked to BDNF-ERK signaling and norepinephrine.

bioRxiv · Oct 27, 2025 · PreprintAnimal Behavior & Cognition

Behavioral susceptibility and resilience following early-life stress are associated with sex-dependent locus coeruleus noradrenergic signatures in adulthood

Déa Slavova, Valentine Greffion, Lionel Granjon, Stéphanie De Gois, Maud Blaise, Bruno Giros A, Elsa Isingrini

This study links early-life stress outcomes to sex-dependent locus coeruleus-norepinephrine system activation in mice, revealing distinct behavioral and neurobiological patterns.

bioRxiv · Oct 11, 2025 · PreprintNeuroscience

A post-mortem investigation of the locus coeruleus- noradrenergic system in resilience to childhood abuse

Déa Slavova, Maria Antonietta Davoli, Céline Keime, Gabriella Frosi, Érika Vigneault, Corina Nagy, Gustavo Turecki, Bruno Giros A, Naguib Mechawar, Elsa Isingrini

The paper investigates how childhood abuse affects the locus coeruleus-noradrenergic system in post-mortem brain samples, finding reduced neuron density and differential gene expression in resilient individuals.

bioRxiv · Mar 22, 2025 · PreprintNeuroscience

Unexpected contributions of striatal projection neurons coexpressing dopamine D1 and D2 receptors in balancing motor control

Patricia Bonnavion, Christophe Varin, Gohar Fakhfouri, Pilar Martinez Olondo, Aurélie De Groote, Amandine Cornil, Ramiro Lorenzo Lopez, Elisa Pozuelo Fernández, Elsa Isingrini, Quentin Rainer, Kathleen Xu, Eleni T. Tzavara, Érika Vigneault, Sylvie Dumas, Alban de Kerchove d’Exaerde, Bruno Giros A

The paper identifies D1/D2 coexpressing striatal projection neurons as critical for modulating motor function through interactions with D1- and D2-SPNs.

Nature Neuroscience · Jul 4, 2024Peer-reviewedNeuroscience

Behavioral and transcriptomic changes following brain-specific loss of noradrenergic transmission.

Elsa Isingrini, Chloé Guinaudie, Léa C. Perret, Elisa Guma, Victor Gorgievski, Ian David Blum, Jessica Colby-Milley, Maryia Bairachnaya, Sébastien Mella, Antoine Adamantidis, Kai-Florian Storch, Bruno Giros A

This study investigates the effects of brain-specific noradrenergic depletion on behavior and gene expression, finding anxiolytic effects and altered gene regulation in vulnerable brain regions.

Biomolecules · Mar 10, 2023Peer-reviewedNeuroscience

Regulation of GluA1 Phosphorylation by D-amphetamine and Methylphenidate in the Cerebellum

Laura Cutando, Emma Puighermanal, Laia Castell, Pauline Tarot, Federica Bertaso, Patricia Bonnavion, Alban de Kerchove d’Exaerde, Elsa Isingrini, Micaela Galante, Glenn M. Dallérac, Vincent Pascoli, Christian Lüscher, Bruno Giros A, Emmanuel Valjent

This paper shows that d-amphetamine and methylphenidate increase GluA1 phosphorylation at Ser845 in mouse cerebellar Bergmann Glia Cells via norepinephrine signaling.

Addiction Biology · Dec 26, 2020Peer-reviewedNeuroscience