Amandine Chaix

This study compares the effects of tirzepatide and caloric restriction on hematopoiesis in obese mice, finding tirzepatide preserves HSPC cycling and reduces inflammatory monocytes while CR causes cytopenias.

This study shows that semaglutide causes muscle loss in male ob/ob mice but not in female ob/ob mice, revealing sex-specific effects on skeletal muscle mass and metabolism.

This study shows that N-acetylcarnosine treatment improves survival and delays age-related decline in multiple organ systems in female mice.

This study shows that hyperlipidemia, not obesity alone, drives breast cancer growth in mice, suggesting lipid-lowering therapies could reduce cancer risk in obese individuals.

Deletions of conserved cis-elements tied to hibernator evolution causes diverse metabolic traits in mice.

This study shows semaglutide improves mitochondrial energy efficiency in skeletal muscle by enhancing ATP production per oxygen consumed during weight loss.