Kees Jalink

This study visualizes homology search dynamics in living human cells using GFP-MND1, revealing filament structures that resolve over time and depend on RAD54L and cohesin.

The paper develops a high-throughput live-cell screening platform using time-lapse FRET-FLIM to study dynamic signaling phenotypes, demonstrating its effectiveness in identifying regulators of cAMP signaling.

The paper presents and characterizes mutations that improve cytosolic localization in FLIM-based cAMP FRET sensors while maintaining performance.

The paper introduces a new 3C method, MC-4C, to study multi-way DNA conformations and reveals cooperative and competitive chromatin interactions, including enhancer hubs and loop collisions.